Answer:
If the patient meets the Indications and Conditions (and none of the Contraindications) for the Moderate to Severe Allergic Reaction Medical Directive, then you should treat the patient per the Medical Directive. For further reference on differentiating an anaphylactic reaction for a local reaction, please see the most up to date version of the OBHG Companion Document pages 14-15 (here).
It is important to note that these patients, once treated under this Medical Directive should then be transported to hospital. Furthermore, these directives are to be utilized only as a 9-1-1 response paramedic, thus an ACR with a CACC issued run number is required. If you are a first response vehicle, you will need to call a 2nd crew to transport them to hospital.